M344 - HDAC Inhibitor

M344 is a novel synthesized histone deacetylase inhibitor that induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. Antiproliferative agent; suppresses the growth of human endometrial and ovarian cancer cells by inducing cell cycle arrest and apoptosis.

IUPAC Name: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
Molecular Weight: 307.40 g/mol
Molecular Formula: C16H25N3O3
SMILES: ONC(=O)CCCCCCNC(=O)c(cc1)ccc1N(C)C
Canonical SMILES: CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO
InChIKey Identifier: MXWDSZWTBOCWBK-UHFFFAOYSA-N
CAS Number: 251456-60-7
Melting point: n/a °C
Solubility: : 3 mg/mL in ethanol; 25 mg/mL in DMSO and DMF
2D Molfile: Get the molfile
Synonyms: M344; D237; 4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)-benzamide

M344 can be considered as highly potent HDAC inhibitor which is active at low doses and therefore represents a promising candidate for a causal therapy of SMA.

References:
1) Markus Riessland, Lars Brichta, Eric Hahnen, Brunhilde Wirth. The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells. Hum Genet (2006) 120:101–110
2) Jung M, Brosch G, Kolle D et al (1999). Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation. J Med Chem 1999; 42:4669